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The main purpose of hydrocodone 5–325 mg is to treat moderate–to-severe pain. Its two primary ingredients are hydrocodone, an opioid painkiller, and acetaminophen, a non-opioid analgesic and antipyretic. Acetaminophen reduces fever and pain, while hydrocodone changes how your brain and central nervous system perceive and react to pain. Because this medication can be addictive and misused, you must take it exactly as prescribed by your doctor.