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Foods To Avoid While Taking Letrozole, it is advisable to avoid certain foods that may interact with the medication or exacerbate its side effects. Grapefruit and its juice should be avoided, as they can interfere with the liver enzymes responsible for metabolizing letrozole, potentially affecting its effectiveness. Additionally, consuming high-calcium foods or supplements simultaneously with letrozole may reduce its absorption, so it’s recommended to separate their intake by a few hours. Alcohol intake should be moderated or avoided, as it may increase the risk of liver complications associated with letrozole.